This systematic review of literature examines and synthesizes research findings related to interventions for people with work-related elbow injuries, particularly epicondylitis. It was carried out as part of the Evidence-Based Literature Review Project of the American Occupational Therapy Association. The 11 articles included in this review suggest multiple approaches to intervention but do not provide sufficient evidence to determine which methods or approaches are best practice. Research has provided little evidence to support the use of commonly prescribed interventions for epicondylitis, the most frequently reported work-related elbow injury. Collectively, the evidence to support the use of splinting, exercise, or physical agent modalities is weak and provides little guidance for approaching management of elbow injuries. The implications for education and research are discussed, as is the application of the evidence to clinical practice in occupational therapy.