Obesity is a health disparity related to environmental, social, and physical health issues, including ethnicity, education, and gender. The purpose of this study was to examine the relationship among obesity, age, education, and socioeconomic status and the relationship between obesity and depression among African-American women living in Omaha, Nebraska. A convenience sample of 378 African-American women completed the African-American Female Health Survey, which included the Center for Epidemiologic Studies Depression scale. Body mass index (BMI) was used to measure obesity. Results indicated that 87% of the women were overweight; mean BMI was 32.78 with high cardiovascular disease risks. There was a statistically significant and positive relationship between depression and BMI (r = .201, p < .01). Occupational therapists may provide primary, secondary, and tertiary intervention through culturally relevant and meaningful health education programs.