Using the clinical phenomenon of posttraumatic stress disorder related to traumatic hand injuries, this article conceptually explores the theoretical construct of neuro-occupation on the basis of these conditions. Neuro-occupation is an evolving concept that combines knowledge and understanding of occupation with knowledge and understanding of how the human brain functions in environmental context; thus, the concept is important to the core of occupational therapy practice. The first section of the article introduces the concept of neuro-occupation; the second provides an overview of posttraumatic stress disorder and traumatic hand injury. To help therapists better understand behavior seen in clinical settings, the third section presents key neuro-occupational processes pertaining to posttraumatic stress disorder, using clinical application examples. Finally, a query about the value of neuro-occupation as a developing theoretical construct is put forth.